LymphedemaV1, Main, Exploration, bibRecord, 003803

Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment

Identifieur interne : 003803 ( Main/Exploration ); précédent : 003802; suivant : 003804

Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment

Auteurs : Swati Rane [États-Unis] ; Paula M. C. Donahue [États-Unis] ; Ted Towse [États-Unis] ; Sheila Ridner [États-Unis] ; Michael Chappell [États-Unis] ; John Jordi [Royaume-Uni] ; John Gore [États-Unis] ; Manus J. Donahue [États-Unis]

Source :

Radiology [ 0033-8419 ] ; 2013.

RBID : PMC:4485559

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique (), Lymphe (physiologie), Lymphoedème (anatomopathologie), Marqueurs de spin, Mâle, Études de faisabilité.
MESH :
- anatomopathologie : Lymphoedème.
- physiologie : Lymphe.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Marqueurs de spin, Mâle, Études de faisabilité.

English descriptors

KwdEn :
- Adult, Feasibility Studies, Female, Humans, Lymph (physiology), Lymphedema (pathology), Magnetic Resonance Imaging (methods), Male, Middle Aged, Spin Labels.
MESH :
- chemical : Spin Labels.
- methods : Magnetic Resonance Imaging.
- pathology : Lymphedema.
- physiology : Lymph.
- Adult, Feasibility Studies, Female, Humans, Male, Middle Aged.

Abstract

Purpose

To extend a commonly employed, noninvasive arterial spin labeling (ASL) MRI method for measuring blood flow to evaluate lymphatic flow.

Materials and Methods

All volunteers (n=12) provided informed consent in accordance with IRB and HIPAA regulations. Quantitative relaxation time (T₁ and T₂) measurements were made in extracted human lymphatic fluid at 3.0T. Guided by these parameters, an ASL MRI approach was adapted to measure lymphatic flow (flow-alternating-inversion-recovery lymphatic water labeling; 3×3×5 mm³) in healthy subjects (n=6; 30±1 yrs; recruitment duration=2 months). Lymphatic flow velocity was quantified by performing spin labeling measurements as a function of post-labeling delay time and measuring the time-to-peak of signal in axillary lymph nodes. Clinical feasibility was evaluated in Stage II lymphedema patients (n=3; 60yr/F, 43yr/F, 64yr/F) and control subjects with unilateral cuff-induced lymphatic stenosis (n=3; 31yr/M, 31yr/M, 35yr/F).

Results

T₁ and T₂ of lymphatic fluid at 3.0T were 3100±160 ms (range=2930-3210 ms; median=3200 ms) and 610±12 ms (range=598-618 ms; median=610 ms), respectively. Healthy lymphatic flow (afferent vessel to axillary node) velocity was found to be 0.61±0.13 cm/min (n=6). A reduction (P<0.005) in lymphatic flow velocity in the affected arms of patients and the affected arms of healthy subjects with manipulated cuff-induced flow reduction was observed. The ratio of unaffected to affected axilla lymphatic velocity (1.24±0.18) was significantly (P<0.005) higher than the Left/Right ratio in healthy subjects (0.91±0.18).

Conclusion

This work provides a foundation for clinical investigations whereby lymphedema etiogenesis and therapies may be interrogated without exogenous agents and with clinically available imaging equipment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485559

DOI: 10.1148/radiol.13120145
PubMed: 23864103
PubMed Central: 4485559

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph (physiology)</term>
<term>Lymphedema (pathology)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Spin Labels</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique ()</term>
<term>Lymphe (physiologie)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Marqueurs de spin</term>
<term>Mâle</term>
<term>Études de faisabilité</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Spin Labels</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Marqueurs de spin</term>
<term>Mâle</term>
<term>Études de faisabilité</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">To extend a commonly employed, noninvasive arterial spin labeling (ASL) MRI method for measuring blood flow to evaluate lymphatic flow.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P2">All volunteers (n=12) provided informed consent in accordance with IRB and HIPAA regulations. Quantitative relaxation time (<italic>T</italic>
<sub>1</sub>
 and <italic>T</italic>
<sub>2</sub>
) measurements were made in extracted human lymphatic fluid at 3.0T. Guided by these parameters, an ASL MRI approach was adapted to measure lymphatic flow (flow-alternating-inversion-recovery lymphatic water labeling; 3×3×5 mm<sup>3</sup>
) in healthy subjects (n=6; 30±1 yrs; recruitment duration=2 months). Lymphatic flow velocity was quantified by performing spin labeling measurements as a function of post-labeling delay time and measuring the time-to-peak of signal in axillary lymph nodes. Clinical feasibility was evaluated in Stage II lymphedema patients (n=3; 60yr/F, 43yr/F, 64yr/F) and control subjects with unilateral cuff-induced lymphatic stenosis (n=3; 31yr/M, 31yr/M, 35yr/F).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3"><italic>T</italic>
<sub>1</sub>
 and <italic>T</italic>
<sub>2</sub>
 of lymphatic fluid at 3.0T were 3100±160 ms (range=2930-3210 ms; median=3200 ms) and 610±12 ms (range=598-618 ms; median=610 ms), respectively. Healthy lymphatic flow (afferent vessel to axillary node) velocity was found to be 0.61±0.13 cm/min (n=6). A reduction (P<0.005) in lymphatic flow velocity in the affected arms of patients and the affected arms of healthy subjects with manipulated cuff-induced flow reduction was observed. The ratio of unaffected to affected axilla lymphatic velocity (1.24±0.18) was significantly (P<0.005) higher than the Left/Right ratio in healthy subjects (0.91±0.18).</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">This work provides a foundation for clinical investigations whereby lymphedema etiogenesis and therapies may be interrogated without exogenous agents and with clinically available imaging equipment.</p>
</sec>
</div>
</front>
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<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Rane, Swati" sort="Rane, Swati" uniqKey="Rane S" first="Swati" last="Rane">Swati Rane</name>
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<name sortKey="Chappell, Michael" sort="Chappell, Michael" uniqKey="Chappell M" first="Michael" last="Chappell">Michael Chappell</name>
<name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name>
<name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name>
<name sortKey="Donahue, Manus J" sort="Donahue, Manus J" uniqKey="Donahue M" first="Manus J." last="Donahue">Manus J. Donahue</name>
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<name sortKey="Gore, John" sort="Gore, John" uniqKey="Gore J" first="John" last="Gore">John Gore</name>
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   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4485559
   |texte=   Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment
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Serveur d'exploration sur le lymphœdème

Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment

Clinical Feasibility of Noninvasive Visualization of Lymphatic Flow using Principles of Spin Labeling MRI: Implications for Lymphedema Assessment

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	Serveur d'exploration sur le lymphœdème
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